Annals of African Medicine

ORIGINAL ARTICLE
Year
: 2022  |  Volume : 21  |  Issue : 4  |  Page : 316--321

The evaluation of serum lipid profile in chronic Hepatitis B patients at a Tertiary Care Centre in Western India: A cross-sectional study


Durga Shankar Meena1, Deepak Kumar1, Mahendra Kumar Garg1, Mahadev Meena1, Bharat Seju1, Gopal Krishana Bohra1, Naresh Kumar Midha1, Mithu Banerjee2 
1 Department of Internal Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
2 Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India

Correspondence Address:
Deepak Kumar
Department of Internal Medicine, All India Institute of Medical Sciences, Jodhpur - 342 005, Rajasthan
India

Introduction: Hepatitis B virus (HBV) is known as a metabolovirus due to its impact on lipid and glucose metabolism in the liver. Previous literature showed a trend of hypolipidemia and reduced risk of metabolic syndrome in hepatitis B surface antigen-positive patients. However, data from the Indian population are lacking. We evaluate the relation of lipid profile with HBV infection and severity of liver disease. Materials and Methods: This was an observational cross-sectional study in which 50 patients with chronic hepatitis B and 43 anthropometrically matched seronegative controls were enrolled. Demographical, clinical, and laboratory data including lipid profile (high-density lipoprotein [HDL], low-density lipoprotein [LDL], triglycerides, and total cholesterol [TC]) were collected. Seropositive patients were categorized based on prognostic models (model for end-stage liver disease [MELD] and Child-Pugh score) for further analysis. Results: Our study revealed significant low levels of serum TC, HDL, and LDL cholesterol in hepatitis B patients compared to seronegative controls (133.06 vs. 162.39, 35.56 vs. 43.65, and 76.62 vs. 99.95 mg/dl respectively, P < 0.05). The patients with high MELD and Child-Pugh score were associated with hypolipidemia. Significant low levels of LDL and TC were observed in Child-Pugh class C in comparison to class A (94.8 vs. 149.2 and 50.6 vs. 87.9 mg/dl respectively, P < 0.05). Conclusions: A significant reduction in various lipid parameters was seen with chronic hepatitis B. Furthermore, prognostic score (high MELD and Child-Pugh score) were associated with hypolipidemia.


How to cite this article:
Meena DS, Kumar D, Garg MK, Meena M, Seju B, Bohra GK, Midha NK, Banerjee M. The evaluation of serum lipid profile in chronic Hepatitis B patients at a Tertiary Care Centre in Western India: A cross-sectional study.Ann Afr Med 2022;21:316-321


How to cite this URL:
Meena DS, Kumar D, Garg MK, Meena M, Seju B, Bohra GK, Midha NK, Banerjee M. The evaluation of serum lipid profile in chronic Hepatitis B patients at a Tertiary Care Centre in Western India: A cross-sectional study. Ann Afr Med [serial online] 2022 [cited 2022 Nov 29 ];21:316-321
Available from: https://www.annalsafrmed.org/article.asp?issn=1596-3519;year=2022;volume=21;issue=4;spage=316;epage=321;aulast=Meena;type=0