Year : 2016 | Volume
: 15 | Issue : 3 | Page : 97--103
Ocular manifestations in leukemia and myeloproliferative disorders and their association with hematological parameters
Renu Dhasmana1, Amrita Prakash1, Neeti Gupta1, SK Verma2
1 Department of Ophthalmology, Swami Rama Himalayan University, Dehradun, Uttarakhand, India
2 Department of Medicine, Swami Rama Himalayan University, Dehradun, Uttarakhand, India
Objectives: To study the ocular manifestations in patients diagnosed with leukemia or myeloproliferative disorders and to derive an association between the ocular manifestations and hematological parameters of the patients.
Materials and Methods: This observational and descriptive study was conducted in a Tertiary Care Center of Dehradun, North India over a period of 1 year. All the diagnosed cases of leukemia and myeloproliferative diseases attending the Oncology Department were included. Patients underwent a detailed ocular examination. The hematological parameters were also recorded including hemoglobin (Hb), total leukocyte count (TLC), and platelet count.
Results: The study included 102 patients out of which, there were 66 males (64.7%), and 36 were females (35.3%) with an age range of 5-80 years. A total of forty patients showed ocular manifestations (39.3%). Extraocular manifestations were seen in 10.8% patients while intraocular manifestations were noted in 45.1% patients of acute leukemia and 7.7% patients of chronic leukemia. These ocular manifestations showed a significant association with low Hb (P = 0.000), raised TLC (P = 0.004), and low platelet count (P = 0.000). The most common ocular manifestation was intraretinal hemorrhages followed by roth spots. Among acute myeloid leukemia patients (23.5%), the presence of intraretinal hemorrhages was significantly associated with low Hb (Mann-Whitney U-test = 25.000, P = 0.007). The patients of acute lymphoblastic leukemia (25.4%) showed significant association between intraretinal hemorrhages and low platelet count (Mann-Whitney U-test = 44.000, P = 0.046) and roth spots with low Hb (Mann-Whitney U-test = 11.000, P = 0.000). Ocular manifestations were more commonly seen in acute leukemias as compared to chronic leukemias.
Conclusion: Ocular examination is recommended in all leukemic patients as ocular manifestations may go unnoticed, most patients being asymptomatic and could be an early sign of worsening of disease.
Department of Ophthalmology, Swami Rama Himalayan University, Dehradun - 248 001, Uttarakhand
|How to cite this article:|
Dhasmana R, Prakash A, Gupta N, Verma S K. Ocular manifestations in leukemia and myeloproliferative disorders and their association with hematological parameters.Ann Afr Med 2016;15:97-103
|How to cite this URL:|
Dhasmana R, Prakash A, Gupta N, Verma S K. Ocular manifestations in leukemia and myeloproliferative disorders and their association with hematological parameters. Ann Afr Med [serial online] 2016 [cited 2022 May 25 ];15:97-103
Available from: https://www.annalsafrmed.org/article.asp?issn=1596-3519;year=2016;volume=15;issue=3;spage=97;epage=103;aulast=Dhasmana;type=0