Annals of African Medicine
Home About AAM Editorial board Ahead of print Current Issue Archives Instructions Subscribe Contact us Search Login 
ORIGINAL ARTICLE
Year : 2022  |  Volume : 21  |  Issue : 1  |  Page : 58-64

Cholelithiasis in children and adolescents with sickle cell disease: Experience in a resource-limited setting


1 Department of Paediatrics, Paediatric Gastroenterology Unit, College of Medicine, Lagos University Teaching Hospital, University of Lagos, Idi-Araba, Nigeria
2 Department of Internal Medicine, Gastroenterology Unit, College of Medicine, Lagos University Teaching Hospital, University of Lagos, Lagos, Nigeria
3 Department of Radiology, College of Medicine, Lagos University Teaching Hospital, University of Lagos, Lagos, Nigeria
4 Department of Radiology, Lagos University Teaching Hospital, College of Medicine, Lagos University Teaching Hospital, University of Lagos, Lagos, Nigeria
5 Department of Surgery, Paediatric Surgery Unit, Lagos University Teaching Hospital, Lagos, Nigeria
6 Department of Paediatrics, Oncology Unit, College of Medicine, Lagos University Teaching Hospital, University of Lagos, Idi-Araba, Nigeria

Correspondence Address:
Oluwafunmilayo Funke Adeniyi
Department of Paediatrics, Paediatric Gastroenterology Unit, College of Medicine, Lagos University Teaching Hospital, University of Lagos, Idi-Araba, Lagos
Nigeria
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/aam.aam_81_20

Rights and Permissions

Background: Sickle cell disease (SCD) remains prevalent in Nigeria and can be complicated by cholelithiasis even in children. There is still a dearth of knowledge about the occurrence of cholelithiasis in these children. The present study is aimed to determine the prevalence of cholelithiasis in pediatric SCD in Lagos and documents relevant socio-demographic and clinical correlates. Subjects and Methods: This was a cross-sectional study of children and adolescents aged 1–19 years with SCD attending the Paediatric Haematology Clinic of the Lagos University Teaching Hospital. One hundred and forty-seven children were consecutively recruited into the study over 3 months and they all had sonographic examination of the gall bladder. The association between cholelithiasis, sociodemographic data, clinical symptoms, laboratory parameters, and the use of hydroxyurea was also documented. Results: The median age (range) of the study participants was 9.0 (1–19) years and majority were males (59.9%). The prevalence of cholelithiasis was 13.6% and the condition was most prevalent in adolescents (21.4%) compared to the younger children (6.5%). All the children with cholelithiasis were asymptomatic. Age and the frequency of crisis were significantly associated with cholelithiasis on multivariate analysis (P = 0.03, 0.045, respectively). The use of hydroxyurea was not significantly related to the occurrence of cholelithiasis. Conclusion: The prevalence of cholelithiasis observed in this study is high. Routine screening of older children and adolescents with SCD, especially with the frequent crisis is suggested. Longitudinal studies to establish the relationship between hydroxyurea and cholelithiasis is also advocated.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed626    
    Printed16    
    Emailed0    
    PDF Downloaded2    
    Comments [Add]    

Recommend this journal