|Year : 2019 | Volume
| Issue : 3 | Page : 158-166
Intima-media thickness of femoral arteries and carotids among an adult hypertensive Nigerian population: A case–control study to assess their use as surrogate markers of atherosclerosis
Mayowa Abimbola Soneye1, Ademola Joseph Adekanmi2, Millicent Olubunmi Obajimi2, Akinyemi Aje3
1 Department of Radiology, University College Hospital, Ibadan, Nigeria
2 Department of Radiology, College of Medicine, University of Ibadan, Ibadan, Nigeria
3 Department of Medicine, Cardiology Unit, University College Hospital, Ibadan, Nigeria
|Date of Web Publication||14-Aug-2019|
Dr. Ademola Joseph Adekanmi
Department of Radiology, College of Medicine, University of Ibadan, Ibadan
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Background: Increased intima-media thickness (IMT) is an established and important surrogate marker for atherosclerosis. Intima-media thickening in the femoral arteries occur earlier and reflect the true extent of generalized atherosclerosis better than in the carotids. Aims: To study the ultrasound-detected morphological changes in the common femoral versus carotid artery wall. Patients and Methods: A case-control study design was used, with 61 adult hypertensive as cases and 61 age-, sex- and BMI-matched normotensive as controls. Variables were participants' characteristics, cardiovascular risk factors, and ultrasonographically evaluated IMT of the carotid and femoral arteries. Results: A total of 122 participants were studied. The mean femoral IMT in hypertensives and controls on the right and left was 0.63 ± 0.07mm vs. 0.52 ± 0.06mm [P < 0.0001] and 0.69 ± 0.0 mm vs. 0.55 ± 0.05mm [P < 0.0001]. Also, the mean carotid IMT among hypertensives and controls on the right =0.80 ±0.15mm vs. 0.64 ± 0.06mm [P < 0.0001], and 0.91 ± 0.22mm vs. 0.65 ± 0.06mm [P < 0.0001] on the left. Significant correlation was observed between IMT and age (B = 0.006, P < 0.001 and B = 0.003, P < 0.001), hypertension (B = 0.205, P < 0.001 and B = 0.122, p<0.001), and duration of hypertension (B = 0.02, P < 0.001 and B = 0.006, P = 0.02) the femoral and carotid arteries respectively. Conclusion: The femoral and the carotid artery show similar significantly increased IMT in hypertensive adults. The femoral IMT appears to be a good surrogate marker of atherosclerosis among hypertensive Nigerians.
| Abstract in French|| |
Contexte: L'épaisseur accrue de l'intima-média (IMT) est un marqueur de substitution établi et important de l'athérosclérose. L'épaississement intima-média dans les artères fémorales survient plus tôt et reflète mieux l'étendue réelle de l'athérosclérose généralisée que dans les carotides. Objectifs: étudier les modifications morphologiques détectées par échographie dans la paroi de l'artère fémorale commune par rapport à la carotide. Patients et méthodes: Un schéma d'étude cas-témoins a été utilisé, avec 61 adultes hypertensifs en tant qu'études des cas et 61 normo-tensifs appariés pour l'âge, le sexe et l'IMC en tant que contrôles. Les variables étaient les caractéristiques des participants, les facteurs de risque cardiovasculaires et les TMI évaluées par échographie des artères carotides et fémorales. Résultats: Un total de 122 participants ont été étudiés. Le TMI fémoral moyen chez les hypertensifs et chez les témoins de droite et de gauche était de 0,63 ± 0,07 mm contre 0,52 ± 0,06 mm [P <0,0001] et de 0,69 ± 0,0 mm contre 0,55 ± 0,05 mm [P <0,0001]. En outre, la moyenne IMT carotidienne chez les hypertendus et les contrôles à droite = 0,80 ± 0,15 mm vs 0,64 ± 0,06 mm [P <0,0001] et 0,91 ± 0,22 mm contre 0,65 ± 0,06 mm [p < 0,0001] à gauche. Une corrélation significative a été observée entre les TMI et l'âge (B = 0,006, p < 0,001 et B = 0,003, p < 0,001), l'hypertension (B = 0,205, p <0,001 et B = 0,122, p <0,001) et la durée de l'hypertension (B = 0,02, p < 0,001 et B = 0,006, p = 0,02) respectivement des artères fémorale et carotide. Conclusion: Les artères fémorales et carotide montrent une augmentation similaire du TMI chez les adultes hypertensifs. L'IMT fémoral semble être un bon marqueur de substitution de l'athérosclérose chez les Nigérians hypertensifs.
Keywords: Atherosclerosis, carotid artery, femoral artery, hypertension, intima-media thickness, ultrasonography
|How to cite this article:|
Soneye MA, Adekanmi AJ, Obajimi MO, Aje A. Intima-media thickness of femoral arteries and carotids among an adult hypertensive Nigerian population: A case–control study to assess their use as surrogate markers of atherosclerosis. Ann Afr Med 2019;18:158-66
|How to cite this URL:|
Soneye MA, Adekanmi AJ, Obajimi MO, Aje A. Intima-media thickness of femoral arteries and carotids among an adult hypertensive Nigerian population: A case–control study to assess their use as surrogate markers of atherosclerosis. Ann Afr Med [serial online] 2019 [cited 2022 Aug 13];18:158-66. Available from: https://www.annalsafrmed.org/text.asp?2019/18/3/158/264321
| Introduction|| |
Increased intima-media thickness (IMT), the first structural change detected in atherosclerosis, is an important surrogate marker in atherosclerosis. IMT assessed in the peripheral large arteries is known to correlate significantly with the presence and progression of atherosclerosis in smaller arteries such as the coronary arteries. IMT measurements have become a proven tool in the selection of high-risk patients and to evaluate the efficacy of therapy., Although advancing age, sex, diabetes, and hypercholesterolemia have been identified as independent risk factors for abnormal IMT or atherosclerosis, hypertension, which leads to complex interactions of increased smooth muscle mass, connective tissues deposition, endothelial dysfunction, and impaired production of endothelium-derived relaxing factors, is a proven and a major cause of arterial wall thickening.,
While hypertension remains an important risk factor for the development of generalized atherosclerosis, it has also been implicated as a major risk factor in cardiovascular disease. Hypertension, a chronic medical condition in which blood pressure measurement is at or above a systolic to diastolic blood pressure (DBP) of 140/90 mmHg, is the most common cardiovascular disease in blacks including Nigerians, with a prevalence rate of 10%–48.8%.,,,
Recent reports have shown an increasing prevalence in Africa and beyond, with the developing countries projected to have an enormous share of this rising global burden of hypertension, accounting for about 75% of the world's hypertensive patient population by the year 2025. The increasing prevalence of hypertension in low- and middle-income countries such as Nigeria is also associated with an increase in mortality rates from its complications, including stroke, cardiac failure, and renal diseases.
It is, therefore, imperative to have a simple but precise measurable indicator of atherosclerosis in this group of patients. Among many imaging modalities, B-mode ultrasonographic measurement of IMT has emerged as one of the best methods for evaluating early atherosclerosis, thus helping in the implementation of early treatment.
A recent large population study validated IMT measurement as a valid noninvasive method of monitoring atherosclerotic changes, particularly the progression of IMT and increased plaque burden in the carotid arteries. IMT, an established surrogate marker of generalized atherosclerosis,,, particularly of the carotids, is an established method in the evaluation of cardiovascular disease morbidity or mortality and for the study of associations with risk factors ,, and coronary or cerebrovascular events.,,,,,
Although atherosclerosis is a generalized disease process, the extent of atherosclerosis and its effects is known to differ in different vascular beds. In the carotid artery, for example, the intima layer is majorly involved in the intima-media thickening. In the femoral artery, however, the media layer has been documented to be mostly involved in the intima-media thickening process. There is competent and corroborative evidence that cardiovascular risk factors and events are significantly related to an increased IMT in the carotid and the femoral arteries.,,,,,,,,,, Treatment of these risk factors was documented to decrease or diminish the progression of the IMT, with consequent reduction in cardiovascular events.
Recent advances in ultrasonography have solidified the place of ultrasonography and positioned IMT and plaques assessment as an important tool in cerebrovascular disease evaluation.
It is worthy of note that despite the wide acceptance of carotid IMT (CIMT), the femoral IMT (FIMT) has been documented as a more representative indicator of generalized atherosclerosis. In addition, the femoral artery shows atherosclerosis earlier and at a more advanced stage than the carotid arteries  and yields a better correlation with coronary heart disease and the need for revascularization procedures. While authors have reported the relationship between femoral artery IMT and hypertension in the developed world,, there are no published data on this subject in our population to ascertain if FIMT could be a surrogate marker of atherosclerosis in native black hypertensive Nigerians. In this present investigation, we measured and compared the IMT of the femoral arteries with that of carotid arteries, as a marker of atherosclerosis in adult hypertensive Nigerians. We also assessed if the femoral artery IMT may also be used as a marker of atherosclerosis in hypertensive patients in this population.
| Materials and Methods|| |
This is a prospective case-control study that was carried out in the Department of Medicine (Cardiology unit) and Radiology of a foremost referral Teaching Hospital in South Western Nigeria between January and May 2016. Patients with essential hypertension were enrolled randomly from the Cardiology Clinic of our Institution, and controls were enrolled using the convenience sampling method from the general public and healthy volunteers. This study was approved by the University of Ibadan/University College Hospital Ethical Review Committee.
Adults with only essential hypertension were recruited after the reason for the study and the consent form was adequately explained to the participants, after which the patient either signed or had to thumbprint. To enhance ease of communication, translation was done to the participant in local dialect if there was a need for it.
Those with secondary hypertension, diabetic patients, hypertensives with hyperlipidemia, and hypertensives with previous history of stroke, hypertensives with previous history of coronary heart disease, pregnancy-induced hypertension, unwilling and uncooperative patients, unstable patients, and patients with peripheral arterial disease were all excluded from this study.
Inclusion criteria for controls
Healthy normotensive individuals older than 18 years who were age-, sex-, and body mass index (BMI)-matched with the cases.
Exclusion criteria for controls
Individuals with history of diabetes, unwilling and uncooperative individuals, normotensives with family history of hyperlipidemia, individuals with history of sickle cell disease, individuals with previous history of stroke, and smokers were all excluded from this study.
History of previous cardiovascular disease (stroke, peripheral vascular disease, and cardiac disease), age of the patient, and time since diagnosis of hypertension were obtained and documented. The blood pressure of the patients was measured using an Accuson mercury sphygmomanometer with the patient in seated position after 5 min of rest. Three measurements were taken and the average of the three values recorded for each patient.
The individual height in meters (m) was measured using a stadiometer with the individual standing erect, and the weight in kilogram (kg) was measured using a standing weighing scale that has been zero corrected. The BMI (kg/m 2) was then calculated as weight (kg) ÷ height 2 (m 2). Patients were screened for diabetes mellitus using the fasting blood sugar (normal = 70–110 mg/dl). Fasting lipid profile was used to screen for hyperlipidemia (normal lipid profile – total cholesterol <200 mg/dl, triglycerides <150,200 mg/dl, low-density lipoprotein 80–120 mg/dl, and high-density lipoprotein 35–86 mg/dl).,
B-mode ultrasonographic measurement of the CIMT and FIMT was done using Ultrasonix SonixSP ultrasound machine with a 7.5–10 MHz linear transducer. The procedure was adequately explained to the patients and consent was obtained. The individuals were in the supine position for the examination. Each patient was well positioned with the neck properly exposed and slightly extended for carotid ultrasound scanning. The head was then rotated 45° away from the side under examination and was supported using a pillow. Ultrasound gel was applied to the neck to reduce tissue-air interface. The common carotid arteries were scanned, and IMT of the far wall  of both the arteries were measured after freezing the image. Measurement of IMT was taken from the leading edge of the lumen–intima interface to the opposite media-adventitia interface at 2 cm below the bifurcation of the arteries on both sides., and the IMT measured thrice and the mean recorded [Figure 1]. After the procedure, the rotated neck was returned to the anatomical position, the acoustic coupling gel was completely cleaned off the neck, and the patient made comfortable as much as possible.
|Figure 1: Ultrasound image of the carotid arteries. CCA = Common carotid artery, ECA = External carotid artery, ICA = Internal carotid artery, IMT = Distance between the cyan cross signs (D4) intima-media thickness|
Click here to view
For the B-mode ultrasound measurement of the FIMT, the thigh was adequately exposed and flexed at the hip and knee, and the thigh was externally rotated. The patient was draped and the acoustic gel was applied to the skin of the thigh to minimize the air interface between the probe and skin. The scanning of both common femoral arteries was done, one after the other, just from above the inguinal ligament to its bifurcation into profunda femoris and superficial femoral branches. The IMT was measured twice at the leading edges of lumen–intima interface and of the media-adventitia interface ,, at a point 1–2 cm proximal to the bifurcation of common femoral arteries, and the mean was recorded., This measurement was done at the far wall because of the near wall's gain dependency and unreliability, as shown in [Figure 2].
|Figure 2: Ultrasound image of the common femoral, deep femoral, and superficial femoral arteries. CFA = Common femoral artery, SFA = Superficial femoral artery, DFA = Deep femoral artery, IMT/D2 = Intima-media thickness|
Click here to view
Plaques seen within the vessels were documented as a distinct area of localized thickness with an IMT more than 1.5 mm. The flexed thigh and knee were returned to the neutral position after the procedure and the acoustic coupling gel was completely wiped off after the examination. The scanning time on the average, was about 20 minutes.
The data generated was entered and analyzed using the Statistical Package for the Social Sciences software version 20 (SPSS Inc., Chicago, IL, USA). Frequency tables, percentages, graphs, and means ± standard deviation were used to present the results of the sociodemographic characteristics, anthropometric, and blood pressure measurements of the respondents, after normality test was done. Student's t-test at 95% level of significance was used to measure difference of CIMT and FIMT between categorical variables such as sex (males and females) and study group (cases and controls). Multivariate regression was used to test the correlation between two quantitative variables such as hypertension, age, BMI, and CIMT/FIMT. Chi-square test at 95% level of significance was used to test the association of the presence of carotid and femoral plaques with the study group hypertensive cases and controls. The presence of carotid and femoral plaques were grouped according to the absence or presence of plaques; absent on the right or left side, present on the left, and present right. Two-tailed tests P < 0.05 were considered statistically significant.
| Results|| |
A total of 122 adults participated in this study; 61 had hypertension and the remaining 61 were normotensive controls. The individuals had a slight male (50.8%) preponderance in both cases and control groups [Table 1]. The mean age of the hypertensive patients was 51.05 ± 14.69 years with majority (29.5%) within the age of 51–60 years. The average age for control individuals was 51.2 years. There were no statistical differences in gender, occupation, and educational status between the groups with P > 0.05. The distribution of the educational status of the respondents between cases and control showed that the majority of cases (44.3%) and control (45.9%) groups had tertiary education [Table 1].
Among the hypertensive cases, 31/61 (50.8%) had controlled systolic blood pressure (SBP; <140 mmHg and DBP <90 mmHg). Expectedly, there was significant difference in blood pressure between cases and control.
The mean SBP among hypertensive (134.34 ± 15. 02 mmHg) was significantly higher than the mean SBP among the control group (122.80 ± 10.98 mmHg). Similarly, the mean DBP was significantly higher among hypertensives (82.36 ± 9.24 mmHg) than in the controls (77.11 ± 8.76 mmHg). However, there were no significant differences in weight and height. The BMI also showed no significant differences and majority of the cases 43 (70.5%) and controls 40 (65.5%) also had normal weight [Table 2].
|Table 2: Blood pressure and some anthropometric measurement between hypertensive patients and controls|
Click here to view
Carotid and femoral artery intima-media thickness
The right CIMT (mm) was significantly higher in the hypertensive individuals (0.80 ± 0.15 mm) compared to control group (0.64 ± 0.06 mm), P < 0.001. The mean left CIMT (mm) was also shown to be significantly higher in the hypertensives (0.91 ± 0.22 mm) compared to the control group (0.65 ± 0.06 mm), P < 0.001.
Similarly, the mean right FIMT (mm) was also significantly higher in the hypertensive patients (0.63 ± 0.07 mm) compared to control group (0.52 ± 0.06 mm), P < 0.001. The mean FIMT on the left was also significantly higher in the hypertensive (0.69 ± 0.09 mm) than the control group (0.55 ± 0.05 mm), P < 0.0001 as shown in [Table 3].
|Table 3: Carotid and femoral intima-media thickness in adult hypertensive cases and controls|
Click here to view
There was a progressive increase in both CIMT and FIMT with increasing age in both cases and control. The mean CIMT was significantly different between age groups in the hypertensives (P < 0.001). Among hypertensive patients age 60 years and above, the mean CIMT (0.99 ± 0.16 mm) was significantly higher than in hypertensives who were within 41–50 years (0.75 ± 0.08, P ≤ 0.001) and those not more than 40 years old (0.71 ± 0.07). Similarly, the mean CIMT was significantly higher among hypertensives who were within 51–60 years (0.93 ± 0.16 mm) than in hypertensives who were within 41–50 years (0.75 ± 0.08 mm) and those were than 40 years old and below (0.71 ± 0.07 mm). However, there was no significant difference in the mean CIMT between hypertensives >60 years and those within 51–60 years age group and between hypertensive patients within age group 41–50 years and those not more than 40 years.
Furthermore, the mean FIMT of hypertensive patients who are above 60 years (0.71 ± 0.05 mm) and the mean FIMT of hypertensive patients who are within 51–60 years old (0.66 ± 0.06 mm) both were statistically significantly higher than mean FIMT of hypertensive patients who are above 60 years (0.71 ± 0.05 mm) and the mean FIMT of hypertensive patients who are within 41–50 years (0.64 ± 0.03 mm) and those aged >40 years (0.59 ± 0.05), P < 0.001. A similar trend was also seen in the control. Normotensive individuals who were above 60 years of age had statistically significant higher mean CIMT (0.73 ± 0.06) than in normotensive individuals who were within 51–60 years (0.63 ± 0.04), 41–50 years (0.62 ± 0.02), and individual not more than 40 years of age (0.60 ± 0.02), P < 0.001. However, there was no statistically significant difference in mean CIMT among the other age groups in normotensive individuals. Furthermore, in the femoral arteries, the normotensive individuals who were above 60 years of age had statistically significant higher mean FIMT (0.60 ± 0.05) than in normotensive individuals who were within 51–60 years (0.52 ± 0.03), 41–50 years (0.53 ± 0.04), and individual not more than 40 years of age (0.50 ± 0.02), P < 0.001 [Table 4].
|Table 4: Factors associated with carotid intima-media thickness and femoral intima-media thickness in hypertensives cases and controls|
Click here to view
Multivariate analysis showed that age and hypertension were independently associated with CIMT and FIMT. There was an increase in CIMT by 0.006 mm for every year increase in age (95% confidence interval [CI] for B: 0.005; 0.007, P < 0.001). Likewise, there was an increase in CIMT by 0.205 mm in hypertensive patients (95% CI for B: 0.169; 0.241, P < 0.001). There was an increase in FIMT by 0.003 mm with an increase in age (95% CI for B: 0.003; 0.004, P < 0.001). Similarly, there was an increase in FIMT by 0.122 mm in hypertensive patients (95% CI for B: 0.105; 0.138, P < 0.001) [Table 5].
|Table 5: Multiple regression of factors influencing common carotid intima-media thickness and femoral intima-media thickness|
Click here to view
There was an increase in CIMT by 0.02 mm for each year increase in the duration of hypertension (95% CI for B: 0.010; 0.022, P < 0.001) [Figure 3]. Furthermore, FIMT increased by 0.006 mm for each year increase in the duration of hypertension (95% CI for B: 0.003; 0.009, P < 0.001) as shown in [Figure 4].
|Figure 3: Regression plot of carotid intima-media thickness against duration of hypertension|
Click here to view
|Figure 4: Regression plot of femoral intima-media thickness against duration of hypertension|
Click here to view
Carotid and femoral plaques
Plaques were seen in the femoral artery in 26.2% (16) of the hypertensive patient and in 18% (11) of the normotensive controls. Femoral plaques were seen more in hypertensive cases than controls, but there was no statistically significant difference(P = 0.276). Similarly, carotid plaques were seen more in hypertensive cases in 26.2% (16) than controls (19.7%; 12 patients), and again, there was no statistically significant association (P = 0.3890) [Table 6].
|Table 6: Association between carotid intima-media thickness and femoral intima-media thickness with plaques|
Click here to view
| Discussion|| |
The mean age of the hypertensive cases in this study is at par with the average age reported in an earlier study in Nigeria. We observed a significantly higher CIMT in hypertensives than in controls, in agreement with the findings of the previous researchers.,,,,, The CIMT (0.92 ± 0.22 mm) in hypertensives in this study is at par with figures from the developed world , and the Jos Nigeria study. This is, however, significantly higher (P < 0.001) than the CIMT measured in hypertensives by Umeh et al. in Ibadan, Nigeria. This may be attributed to continued westernization of our diet and increasing prevalence of hypertension.,, Another reason from the Jos study  may be due to early westernization due to the influx of expatriates into this city with attendant change in, diet, and different prevalence of hypertension.
The left carotid artery has been documented to have higher IMT than the right by Guarini et al. in Italy  and Rosfors et al. in Sweden, similar to our findings in this study. The higher CIMT on the left when compared to the right, in both hypertensives and controls, has been attributed to the fact that the left common carotid artery is a direct branch of the arch of the aorta and it is, and therefore, exposed to higher hemodynamic changes.
The gender of the study population also has significant impact on the CIMT. We observed that the CIMT was higher in males than females, in both cases and controls. This observation is also similar to the findings of Ayoola et al. and Gariepy et al. in France. The higher IMT in males may be due to the higher cardiovascular risk factor levels in males.
The age, gender, and BMI of hypertensive patients, among other factors, are known to be associated with the increased IMT. In this study, the age, gender, and BMI were matched between the cases and controls to remove the confounding effect of these variables on IMT. Nonetheless, we found a strong significant correlation between increasing chronological age and CIMT in hypertensives and normotensives (r = 0.72, P < 0.0001), with a remarkable increase from the 51 to 60 age group and above, as reported by previous authors. However, the relative significant increase in IMT among the hypertensives when compared to the control, as suggested by Plavnik et al., may be due to the additional effect of hypertension on the aging vessels.
In this study, the SBP and DBP were not correlated with CIMT and FIMT as all cases were already on treatment for hypertension. Previous studies where systolic and diastolic pressure were directly correlated with IMT were conducted among new cases, untreated or uncontrolled hypertensive cases, or combination of these cases.,, However, the diagnosis of hypertension among hypertensive cases already on treatment, in this study, had significant effect on the IMT. Hypertension in this study showed independent correlation with IMT, in accordance with the study of Naseh et al. among treated hypertensive cases. Similar findings between hypertension and CIMT were reported among untreated and uncontrolled hypertensives cases studied by Sasaki et al. and Chironi et al., respectively. Furthermore, the duration of hypertension showed significant but moderately positive correlation with the CIMT (r = 0.58, P < 0.001). This may be attributed to the increasing damage that hypertension causes on the vessel wall as the duration of the ailment increases.
There is a paucity of information about the femoral artery IMT in the Nigerian population. The observed FIMT values are significantly higher in hypertensive patients than in the normotensive control individuals, where the mean FIMT values were 0.525 mm on the right and 0.54 mm on the left.
In the previous studies, Rietzschel et al. in Belgium reported a higher mean FIMT in males than in females (0.596 mm vs. 0.511 mm) and Kirhmajer et al., in Spain, observed a higher FIMT in males when compared to females (0.88 mm vs. 0.75 mm). Furthermore, Plavnik et al. in Brazil as well reported a mean of 0.54 mm ± 0.11 mm versus 0.50 mm ± 0.11 mm in males and females, respectively, all in agreement with the findings of a higher FIMT in males when compared to females in this study. The increase in the mean FIMT in males may be due to a similar reason of higher cardiovascular risk factors level in men accounting for higher CIMT values in males.
Furthermore, in the femoral vessels, the age of the hypertensive patients also correlate positively (albeit moderately) and significantly with FIMT in hypertensives in the index study (r = 0.58, P < 0.001). This is in agreement with the findings by Rietzschel et al. This may be attributed to the vascular aging changes and additional effect of hypertension as explained for the carotid arteries IMT increase with age.
Previous studies affirm that age is the strongest determinant of carotid wall thickening, and SBP is considered as a secondary determinant in both hypertensive and normotensives. The duration of hypertensive disease among the cases similarly showed correlation with the FIMT in this study. Similar to our findings in the carotid arteries, hypertension also showed independent correlation with the FIMT.
We observed that plaques were more frequent in the femoral artery when compared with the carotid arteries, in agreement with Wendelhag et al. in Sweden who reported that the femoral artery is exposed to higher hydrostatic pressure and a larger variation of blood pressure than the carotid artery. In the carotid arteries, the plaques were more frequent in the left common carotid artery than in the right common carotid artery, which may be due to the origin of the left common carotid artery which is a direct branch of the aortic arch and therefore exposed to more hemodynamic changes.
A study with a larger sample size in the same locality is recommended to corroborate the findings observed in this study.
| Conclusion|| |
The study shows that FIMT was significantly higher in hypertensives than normotensives, just as the CIMT was. Significant differences existed in CIMT and FIMT in patients with longstanding hypertension. FIMT and CIMT are both accurate markers of atherosclerosis in the study population.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Stein JH, Korcarz CE, Hurst RT, Lonn E, Kendall CB, Mohler ER, et al.
Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: A consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascular Medicine. J Am Soc Echocardiogr 2008;21:93-111.
Korcarz CE, Hirsch AT, Bruce C, DeCara JM, Mohler ER, Pogue B, et al.
Carotid intima-media thickness testing by non-sonographer clinicians: The office practice assessment of carotid atherosclerosis study. J Am Soc Echocardiogr 2008;21:117-22.
Franek E, Januszkiewicz-Caulier J, Błach A, Napora M, Jedynasty K, Budlewski T, et al.
Intima-media thickness and other markers of atherosclerosis in patients with type 2 diabetes and periodontal disease. Kardiol Pol 2012;70:7-13.
Kaul S, Alladi S, Mridula RK, Bandaru SV, Boddu DB, Anjanikumar D, et al.
Prevalence and risk factors of carotid intima-media thickness in asymptomatic individual subjects in a tertiary care center in India. Ann Indian Acad Neurol 2015;18:430-4.
] [Full text]
Arima H, Barzi F, Chalmers J. Mortality patterns in hypertension. J Hypertens 2011;29 Suppl 1:S3-7.
Paul TK, Chen W, Srinivasan SR, He J, Berenson GS. Contrast of the impact of multiple cardiovascular risk factors on the femoral and carotid intima-media thickness in asymptomatic young adults: The bogalusa heart study. Atherosclerosis 2011;216:359-64.
Chobanian AV. Vascular effects of systemic hypertension. Am J Cardiol 1992;69:3E-7E.
Kumar P, Clark ML. Kumar and Clark's Clinical Medicine. 7th
ed. Edinburgh: Elsevier Saunders; 2009. p. 798.
Akinkugbe OO. High Blood Pressure in the African. London England: Churchill Livingstone; 1972. p. 71-4.
Oladapo OO, Salako L, Sodiq O, Shoyinka K, Adedapo K, Falase AO, et al.
A prevalence of cardiometabolic risk factors among a rural Yoruba South-Western Nigerian population: A population-based survey. Cardiovasc J Afr 2010;21:26-31.
Akinlua JT, Meakin R, Umar AM, Freemantle N. Current prevalence pattern of hypertension in Nigeria: A Systematic review. PLoS One 2015;10:e0140021.
Sola AO, Chinyere OI, Stephen AO, Kayode JA. Hypertension prevalence in an urban and rural area of Nigeria. J Med Sci 2013;4:149-54.
Kearney PM, Whelton M, Reynolds K, Whelton PK, He J. Worldwide prevalence of hypertension: A systematic review. J Hypertens 2004;22:11-9.
Sagare SM, Rajderkar SS, Girigosavi BS. Certain modifiable risk factors in essential hypertension: A case- control study. Natl J Community Med 2011;2:9-13.
Wendelhag I, Wiklund O, Wikstrand J. Atherosclerotic changes in the femoral and carotid arteries in familial hypercholesterolemia. Ultrasonographic assessment of intima-media thickness and plaque occurrence. Arterioscler Thromb 1993;13:1404-11.
Rosvall M, Persson M, Östling G, Nilsson PM, Melander O, Hedblad B, et al.
Risk factors for the progression of carotid intima-media thickness over a 16-year follow-up period: The Malmö Diet and cancer study. Atherosclerosis 2015;239:615-21.
Abbasi MR, Abbaszadeh SH, Rokni-Yazdi H, Lessan-Pezeshki M, Khatami MR, Mahdavi-Mazdeh M, et al.
Carotid intima-media thickness as a marker of atherosclerosis in hemodialysis patients. Indian J Nephrol 2016;26:97-101.
] [Full text]
Kirhmajer MV, Banfic L, Vojkovic M, Strozzi M, Bulum J, Miovski Z, et al.
Correlation of femoral intima-media thickness and the severity of coronary artery disease. Angiology 2011;62:134-9.
Kuller L, Borhani N, Furberg C, Gardin J, Manolio T, O'Leary D, et al.
Prevalence of subclinical atherosclerosis and cardiovascular disease and association with risk factors in the cardiovascular health study. Am J Epidemiol 1994;139:1164-79.
Heiss G, Sharrett AR, Barnes R, Chambless LE, Szklo M, Alzola C, et al.
Carotid atherosclerosis measured by B-mode ultrasound in populations: Associations with cardiovascular risk factors in the ARIC study. Am J Epidemiol 1991;134:250-6.
Salonen R, Salonen JT. Determinants of carotid intima-media thickness: A population-based ultrasonography study in Eastern Finnish men. J Intern Med 1991;229:225-31.
Lorenz MW, Markus HS, Bots ML, Rosvall M, Sitzer M. Prediction of clinical cardiovascular events with carotid intima-media thickness: A systematic review and meta-analysis. Circulation 2007;115:459-67.
Nambi V, Chambless L, He M, Folsom AR, Mosley T, Boerwinkle E, et al.
Common carotid artery intima-media thickness is as good as carotid intima-media thickness of all carotid artery segments in improving prediction of coronary heart disease risk in the atherosclerosis risk in communities (ARIC) study. Eur Heart J 2012;33:183-90.
van der Meer IM, Bots ML, Hofman A, del Sol AI, van der Kuip DA, Witteman JC, et al.
Predictive value of noninvasive measures of atherosclerosis for incident myocardial infarction: The rotterdam study. Circulation 2004;109:1089-94.
Johnsen SH, Mathiesen EB, Joakimsen O, Stensland E, Wilsgaard T, Løchen ML, et al.
Carotid atherosclerosis is a stronger predictor of myocardial infarction in women than in men: A 6-year follow-up study of 6226 persons: The Tromsø study. Stroke 2007;38:2873-80.
Mathiesen EB, Johnsen SH, Wilsgaard T, Bønaa KH, Løchen ML, Njølstad I, et al.
Carotid plaque area and intima-media thickness in prediction of first-ever ischemic stroke: A 10-year follow-up of 6584 men and women: The Tromsø study. Stroke 2011;42:972-8.
Ohira T, Shahar E, Iso H, Chambless LE, Rosamond WD, Sharrett AR et al.
Carotid artery wall thickness and risk of stroke subtypes: the atherosclerosis risk in communities study. Stroke 2011;42:397-403.
Cheng KS, Mikhailidis DP, Hamilton G, Seifalian AM. A review of the carotid and femoral intima-media thickness as an indicator of the presence of peripheral vascular disease and cardiovascular risk factors. Cardiovasc Res 2002;54:528-38.
Šrámek A, Reiber JH, Rosendaal F.R. Intima-media thickness measurements in the carotid and femoral artery as an indicator of symptomatic coronary atherosclerosis. KARGER Med Sci Publ 2001;1:249-54.
Fukudome Y, Fujii K, Abe I, Ohya Y, Fukuhara M, Kaseda S, et al.
Ultrasonographic assessment of regional differences in atherosclerotic lesions in patients with hypertension, diabetes mellitus, or both. Hypertens Res 1997;20:175-81.
Naqvi TZ, Lee MS. Carotid intima-media thickness and plaque in cardiovascular risk assessment. JACC Cardiovasc Imaging 2014;7:1025-38.
Bernetti M, Abbate R, Cerini G, Gensini GF, Poggesi L, Boddi M, et al.
Carotid and femoral intima-media thickness as an early atherosclerotic marker. Advantages and limits. G Ital Cardiol (Rome) 2011;12:72-81.
de Sauvage Nolting PR, de Groot E, Zwinderman AH, Buirma RJ, Trip MD, Kastelein JJ, et al.
Regression of carotid and femoral artery intima-media thickness in familial hypercholesterolemia: Treatment with simvastatin. Arch Intern Med 2003;163:1837-41.
Agrawal Y, Goyal V, Chugh K, Shanker V. Reference values of lipid profile for population of Haryana region. Sch J Appl Med Sci 2014;2:1477-83.
Glew RH, Kassam HA, Bhanji RA, Okorodudu A, VanderJagt DJ. Serum lipid profiles and risk of cardiovascular disease in three different male populations in Northern Nigeria. J Health Popul Nutr 2002;20:166-74.
Umeh EO, Agunloye AM, Adekanmi AJ, Adeyinka AO. Ultrasound evaluation of intima-media thickness of carotid arteries in adults with primary hypertension at Ibadan, Nigeria. West Afr J Med 2013;32:62-7.
Rietzschel ER, De Buyzere ML, Duprez DA, Clement DL. Interchangeability of carotid and femoral intima-media thickness in risk stratification. Int Angiol 2001;20:38-46.
Allan PL, Mowbray PI, Lee AJ, Fowkes FG. Relationship between carotid intima-media thickness and symptomatic and asymptomatic peripheral arterial disease. The Edinburgh artery study. Stroke 1997;28:348-53.
Ashley FW Jr., Kannel WB. Relation of weight change to changes in atherogenic traits: The Framingham study. J Chronic Dis 1974;27:103-14.
Held C, Hjemdahl P, Eriksson SV, Björkander I, Forslund L, Rehnqvist N, et al.
Prognostic implications of intima-media thickness and plaques in the carotid and femoral arteries in patients with stable angina pectoris. Eur Heart J 2001;22:62-72.
Gariepy J, Simon A, Massonneau M, Linhart A, Levenson J. Wall thickening of carotid and femoral arteries in male subjects with isolated hypercholesterolemia. PCVMETRA group. Prevention cardio-vasculaire en medecine du travail. Atherosclerosis 1995;113:141-51.
Zhang F, Feng L, Chen Y, Geng Z, Xu X. Relationship between carotid artery intima-media thickness and cardiovascular risk factors in Chinese Uygur population. Int J Clin Exp Med 2014;7:5412-20.
Ayoola OO, Onuwaje MA, Akintomide AO. Sonographic assessment of the carotid intima-media thickness on B-mode ultrasonography in a Nigerian population. Niger Med J 2015;56:357-61.
] [Full text]
Geleijnse JM, Kok FJ, Grobbee DE. Impact of dietary and lifestyle factors on the prevalence of hypertension in Western populations. Eur J Public Health 2004;14:235-9.
Naseh G, Fard MM, Kazemi T, Mirgholami A, Hashemi N, Saburi A, et al.
Comparison of carotid intima-media thickness in hypertensive patients and control group. J Cardiovasc Echogr 2016;26:48-51.
Guarini P, Tedeschi C, Giordano G, Messina V, Cicatiello AM, Strollo L, et al.
Effects of hypertension on intimal-medial thickness, left ventricular mass and aortic distensibility. Int Angiol 1994;13:317-22.
Pruissen DM, Gerritsen SA, Prinsen TJ, Dijk JM, Kappelle LJ, Algra A, et al.
Carotid intima-media thickness is different in large- and small-vessel ischemic stroke: The SMART study. Stroke 2007;38:1371-3.
Okeahialam BN, Alonge BA, Pam SD, Puepet FH. Carotid intima media thickness as a measure of cardiovascular disease burden in Nigerian Africans with hypertension and diabetes mellitus. Int J Vasc Med 2011;2011:327171.
Rosfors S, Hallerstam S, Jensen-Urstad K, Zetterling M, Carlström C. Relationship between intima-media thickness in the common carotid artery and atherosclerosis in the carotid bifurcation. Stroke 1998;29:1378-82.
Plavnik FL, Ajzen S, Kohlmann O Jr., Tavares A, Zanella MT, Ribeiro AB, et al.
Intima-media thickness evaluation by B-mode ultrasound. Correlation with blood pressure levels and cardiac structures. Braz J Med Biol Res 2000;33:55-64.
Sasaki R, Yamano S, Yamamoto Y, Minami S, Yamamoto J, Nakashima T, et al.
Vascular remodeling of the carotid artery in patients with untreated essential hypertension increases with age. Hypertens Res 2002;25:373-9.
Chironi G, Gariepy J, Denarie N, Balice M, Megnien JL, Levenson J, et al.
Influence of hypertension on early carotid artery remodeling. Arterioscler Thromb Vasc Biol 2003;23:1460-4.
Mayet J, Hughes A. Cardiac and vascular pathophysiology in hypertension. Heart 2003;89:1104-9.
Juonala M, Kähönen M, Laitinen T, Hutri-Kähönen N, Jokinen E, Taittonen L, et al.
Effect of age and sex on carotid intima-media thickness, elasticity and brachial endothelial function in healthy adults: The cardiovascular risk in young finns study. Eur Heart J 2008;29:1198-206.
Toikka JO, Laine H, Ahotupa M, Haapanen A, Viikari JS, Hartiala JJ, et al.
Increased arterial intima-media thickness and in vivo
LDL oxidation in young men with borderline hypertension. Hypertension 2000;36:929-33.
[Figure 1], [Figure 2], [Figure 3], [Figure 4]
[Table 1], [Table 2], [Table 3], [Table 4], [Table 5], [Table 6]
|This article has been cited by|
||Lower Plasma Albumin, Higher White Blood Cell Count and High-Sensitivity C-Reactive Protein are Associated with Femoral Artery Intima-Media Thickness Among Newly Diagnosed Patients with Type 2 Diabetes Mellitus
| ||Nga Phi Thi Nguyen, Thuc Luong Cong, Thi Thanh Hoa Tran, Binh Nhu Do, Son Tien Nguyen, Binh Thanh Vu, Lan Ho Thi Nguyen, Manh Van Ngo, Hoa Trung Dinh, Hoang Duong Huy, Nghia Xuan Vu, Kien Nguyen Trung, Duong Ngoc Vu, Nghia The Pham, Tuan Dinh Le |
| ||International Journal of General Medicine. 2022; Volume 15: 2715 |
|[Pubmed] | [DOI]|
||High-dose Cholecalciferol Supplementation Reducing Morning Blood Pressure in Normotensive DM1 Patients
| ||Natércia Neves Marques de Queiroz, Franciane Trindade Cunha de Melo, Fabrício de Souza Resende, Luísa Corrêa Janaú, Norberto Jorge Kzan de Souza Neto, Manuela Nascimento de Lemos, Maria Clara Neres Iunes de Oliveira, Angélica Leite de Alcântara, Lorena Vilhena de Moraes, Apolone da Mota Queiroz, Ícaro José Araújo de Souza, Nivin Mazen Said, Márcia Costa dos Santos, Lilian de Souza D’Albuquerque Silva, Ana Regina Bastos Motta, Melissa de Sá Oliveira dos Reis, Isabel Jane Campos Lobato, Priscila Boaventura Barbosa de Figueiredo, Ana Carolina Contente Braga de Souza, Pedro Paulo Freire Piani, Karem Miléo Felício, João Felício Abrahão Neto, João Soares Felício |
| ||Current Diabetes Reviews. 2021; 17(3): 378 |
|[Pubmed] | [DOI]|
The Association Between Femoral Artery Intima-Media Thickness and Serum Glucagon-Like Peptide-1 Levels Among Newly Diagnosed Patients with Type 2 Diabetes Mellitus
| ||Tuan Dinh Le, Nga Phi Thi Nguyen, Son Tien Nguyen, Hien Thi Nguyen, Hoa Thanh Thi Tran, Thi Ho Lan Nguyen, Cuong Duy Nguyen, Giang Thi Nguyen, Xuan Thanh Nguyen, Bac Duy Nguyen, Son The Trinh, Tuan Anh Ngo, Binh Nhu Do, Thuc Cong Luong |
| ||Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2020; Volume 13: 3561 |
|[Pubmed] | [DOI]|