| ORIGINAL ARTICLE |
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| Year : 2015 | Volume
: 14
| Issue : 2 | Page : 75-81 |
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Prevalence and determinants of cognitive impairment in patients with chronic kidney disease: A cross-sectional study in Benin City, Nigeria
Oghenekaro Godwin Egbi1, Olubunmi Ogunrin2, Efosa Oviasu2
1 Department of Medicine, Niger Delta University Teaching Hospital, Okolobiri; Department of Medicine, Federal Medical Centre, Yenagoa, Bayelsa State, Nigeria
2 Department of Medicine, University of Benin Teaching Hospital, Benin City, Edo State, Nigeria
Correspondence Address:
Oghenekaro Godwin Egbi
Dialysis Unit, Federal Medical Centre, PMB 502, Yenagoa, Bayelsa State
Nigeria
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/1596-3519.149877
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Background: Chronic kidney disease (CKD) has become a public health concern and may be complicated by cognitive impairment (CI) contributing significantly to morbidity and poor prognosis. This hospital-based study aimed at determining the prevalence and the determinants of CI among CKD patients in Nigeria.
Materials and Methods: A total of 190 CKD patients and a 100 healthy control subjects completed this cross-sectional study. Sociodemographic data and history of common clinical features of CKD were obtained with the use of interviewer administered semi-structured questionnaires. The six-item cognitive impairment test was used for assessment of cognitive function of patients and controls.
Results: The prevalence of CI in Stages 3, 4, and 5 CKD patients were 24.0%, 41.6%, and 46.2%, respectively with overall prevalence of 35.3% while only 6.0% of controls had CI (P = 0.03). The most potent determinants of CI were low hematocrit (odds ratio [OR] =3.50), low serum bicarbonate levels (OR = 2.20), and high serum urea (OR = 2.11). Conclusion: CKD is associated with significant CI in Nigerian patients especially with progressive deterioration in renal function. There is a need for regular evaluation of CKD patients for cognitive deficits. |
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