Annals of African Medicine
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Year : 2011  |  Volume : 10  |  Issue : 2  |  Page : 181-184

Penile gangrene due to calcific uremic arteriopathy

1 Department of Medicine, Bayero University, Kano, Nigeria
2 Mayo Clinic Rochester, Minnesota, USA
3 Department of Medicine, Nephrology Unit, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia
4 Department of Medicine, Infectious Disease Unit, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia

Correspondence Address:
Adamu Bappa
Nephrology Unit, Department of Medicine, Aminu Kano Teaching Hospital
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1596-3519.82064

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Calcific uremic arteriopathy (CUA) is a rare but potentially life-threatening complication of end-stage renal disease (ESRD) and secondary hyperparathyroidism. It typically presents with ischemic necrosis involving areas of adiposity in the body mainly the trunk, buttocks, or proximal extremity. Patients can also present with digital ischemia and more rarely penile gangrene. The pathogenesis of CUA is not yet clear but several putative factors, mainly hyperparathyroidism and related metabolic abnormalities are implicated. A number of conditions can mimic CUA clinically and should be differentiated from it. We present in the current study, a patient who presented with progressive penile gangrene and skin necrosis due to CUA. We review the current understanding of the pathogenesis, diagnosis/differential diagnosis, and management of this rare but potentially life-threatening complication of ESRD.

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